MLB Daily Betting Guide: Odds, Schedule, Picks: April 21

Blue Jays Red Sox Baseball
Toronto Blue Jays’ Raimel Tapia, right, is congratulated by Matt Chapman after his two-run home run during the second inning of the team’s baseball game against the Boston Red Sox, Wednesday, April 20, 2022, at Fenway Park in Boston. (AP Photo/Charles Krupa)

In last night’s MLB action, we went exactly .500 on our bets, losing the Tigers-Yankees bet by one run with a meaningless 9th innings run, which hurt. But we’ll look to get over the hump as I take you through today’s schedule, the odds for each game along with the starting pitchers, and some picks that should help you not only enjoy the game but also think about which way you want to want to bet the game if that’s something you want to do.

Also, remember, you don’t HAVE to bet on each game. We are giving you our best bets for every game, but if our analysis isn’t landing with you or you just don’t feel like a bet stands out, it’s okay to give that game a pass. There will always be more games to bet on.

Also, we recommend checking the Fangraphs Probables Grid to see the likely starting pitchers from each game with clickable links to get the most in-depth information on each pitcher.

New to betting? Read our Beginner’s Guide to Betting with a glossary of terms

MLB Odds and Schedule, April 21

Chicago White Sox (6-5) @ Cleveland Guardians (6-5), 1:10 p.m. ET

  • CHW Starting Pitcher: Dylan Cease (2-0, 1.69 ERA, 0.94 WHIP, 13.50 K/9)
  • CLE Starting Pitcher: Zach Plesac (0-1, 1.64 ERA, 1.00 WHIP, 5.73 K/9)
  • Bullpen ERAs: CHW 3.14; CLE 3.35
  • The Pick: 

 

New York Yankees (7-5) @ Detroit Tigers (4-7), 1:10 p.m. ET

  • NYY Starting Pitcher: Jordan Montgomery (0-0, 3.24 ERA, 1.20 WHIP, 6.48 K/9)
  • DET Starting Pitcher: Michael Pineda (9 wins, 3.62 ERA, 1.23 WHIP, 7.24 K/9 in 2021)
  • Bullpen ERAs: NYY 1.98; DET 2.86
  • The Pick: 

 

San Francisco Giants (8-4) @ New York Mets (9-4), 1:10 p.m. ET

  • SF Starting Pitcher: Anthony Desclafani (0-0, 4.32 ERA, 1.68 WHIP, 9.72 K/9)
  • NYM Starting Pitcher: Carlos Carrasco (0-0, 0.84 ERA, 0.66 WHIP, 10.97 K/9)
  • Bullpen ERAs: SF 1.93; NYM 3.28
  • The Pick: 

New York Mets starting pitcher Carlos Carrasco (59) reacts after striking out Arizona Diamondbacks’ Ketel Marte to close the Met’s side in the fifth inning of a baseball game, Saturday, April 16, 2022, in New York. (AP Photo/John Minchillo)

Toronto Blue Jays (7-5) @ Boston Red Sox (6-6), 1:35 p.m. ET

  • TOR Starting Pitcher: Kevin Gausman (0-1, 4.22 ERA, 1.31 WHIP, 11.81 K/9 in 2021)
  • BOS Starting Pitcher: Tanner Houck (1-0, 3.00 ERA, 1.56 WHIP, 7.00 K/9)
  • Bullpen ERAs: TOR 2.98; BOS 3.04
  • The Pick: 

 

For all of our MLB Betting Guides and News, click here

Minnesota Twins (4-8) @ Kansas City Royals (5-5), 2:10 p.m. ET

  • MIN Starting Pitcher: Joe Ryan (1-1, 2.70 ERA, 1.10 WHIP, 9.90 K/9)
  • KC Starting Pitcher: Zack Greinke (0-0, 2.45 ERA, 1.609WHIP, 0.82 K/9)
  • Bullpen ERAs: MIN 4.96; KC 4.25
  • The Pick: 

Baltimore Orioles (4-8) @ Oakland Athletics (7-6), 3:37 p.m. ET

    • BAL Starting Pitcher: Tyler Wells (0-1, 6.35 ERA, 1.76 WHIP, 7.94 K/9)
    • OAK Starting Pitcher: Paul Blackburn (1-0, 1.80 ERA, 0.90 WHIP, 9.00 K/9)
    • Bullpen ERAs: BAL 2.47; OAK 2.72
    • The Pick: 

 

Arizona Diamondbacks (4-8) @ Washington Nationals (6-8), 4:05 p.m. ET

  • ARI Starting Pitcher: Zach Davies (0-1, 5.79 ERA, 1.61 WHIP, 3.86 K/9)
  • WAS Starting Pitcher: Josh Rogers (1-1, 3.72 ERA, 1.24 WHIP, 4.66 K/9)
  • Bullpen ERAs: ARI 4.44; WAS 4.40
  • The Pick: 

 

St. Louis Cardinals (7-3) @ Miami Marlins (4-7), 6:40 p.m. ET

  • STL Starting Pitcher: Jordan Hicks (*Hasn’t pitched more than 10 innings since 2019)
  • MIA Starting Pitcher: Pablo Lopez (1-0, 0.87 ERA, 0.97 WHIP, 6.97 K/9)
  • Bullpen ERAs: STL 1.76; MIA 3.32
  • The Pick: 

Miami Marlins starting pitcher Pablo Lopez throws during the third inning of a baseball game against the Philadelphia Phillies, Friday, April 15, 2022, in Miami. (AP Photo/Lynne Sladky)

Pittsburgh Pirates (5-7) @ Chicago Cubs (6-6), 7:40 p.m. ET

  • PIT Starting Pitcher: Bryse Wilson (0-0, 5.40 ERA, 1.56 WHIP, 4.32 K/9)
  • CHC Starting Pitcher: Mark Leiter Jr. (8 Wins, 3.34 ERA, 1.01 WHIP, 11.12 K/9 in Minors)
  • Bullpen ERAs: PIT 3.12; CHC 3.04
  • The Pick: 

 

Texas Rangers (2-9) @ Seattle Mariners (7-5), 9:40 p.m. ET

  • TEX Starting Pitcher: Taylor Hearn (0-1, 4.70 ERA, 2.09 WHIP, 11.74 K/9)
  • SEA Starting Pitcher: Marco Gonzales (1-1, 3.00 ERA, 1.33 WHIP, 7.00 K/9)
  • Bullpen ERAs: TEX 5.43; SEA 2.37
  • The Pick: 

 

Staff Picks

Here you can keep track of all of our picks for the day’s games:

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